three undergraduates sitting in research facility

UI undergrads tackle pressing health problems

In UI research labs, students learn life lessons and contribute to scientific discovery
Researchers at the UI’s Pappajohn Biomedical Discovery Building are working to eradicate diseases like diabetes, heart disease, and Alzheimer’s—and they rely on undergraduates for help. As early as their first year, UI undergrads get hands-on research experience and make important contributions to their fields.

How diabetes harms the heart

Study in mice reveals heart-damaging pathway triggered by insulin, identifies possible drug targets to prevent or treat heart failure
Research from the University of Iowa and the University of California at Davis finds that two different drugs—a beta blocker and an antidepressant—might both have potential for preventing or treating heart failure associated with diabetes by blocking an insulin signaling pathway in heart muscle.
infant wearing hawkeye gear

UI Children's Hospital nationally ranked by 'U.S. News & World Report'

Eight pediatric specialties included in the 2016-17 Best Children's Hospital rankings
“U.S. News & World Report” has ranked University of Iowa Children’s Hospital in eight specialties in the 2016–17 Best Children’s Hospital rankings. UI Children’s Hospital is the only hospital in Iowa nationally ranked for pediatric care.

Vitamin nicotinamide riboside protects mice from diabetes complications

Nicotinamide riboside lowers blood sugar, reduces fatty liver, and prevents neuropathy in models of prediabetes and type 2 diabetes
A naturally occurring vitamin, nicotinamide riboside (NR), can lower blood sugar levels, reduce fatty liver, and prevent peripheral nerve damage in mouse models of prediabetes and type 2 diabetes (T2D), according to a new study by researchers at the University of Iowa and the Iowa City VA Health Care System.

UI research contradicts conventional wisdom about retinal diabetic neuropathy

Finding shows sequence of events is opposite of what was long believed to be true
For many years, scientists believed diabetic patients developed retinopathy and, as a result of damage to the eye’s blood vessels, later developed neuropathy. In this new study, however, researchers discovered that the sequence of events is just the opposite.

Study identifies liver-generated hormone that regulates 'sweet tooth'

A new University of Iowa-led study, published in “Cell Metabolism,” has identified a hormone that appears to be linked to sugar cravings and consumption. The research could improve diet and help diabetic and obese patients.

Appointments Abel elected to National Academy of Medicine

Dr. E. Dale Abel, the John B. Stokes III professor in diabetes research, professor of internal medicine and biochemistry, and director of the Fraternal Order of Eagles Diabetes Research Center at the University of Iowa Carver College of Medicine, has been elected to the National Academy of Medicine.

Targeting glucose production in liver may lead to new diabetes therapies

Disabling a critical checkpoint for controlling glucose production in the liver reduces blood sugar levels in mouse models of Type 2 diabetes
A new University of Iowa study shows that a biological checkpoint known as the Mitochondrial Pyruvate Carrier (MPC) is critical for controlling glucose production in the liver and could potentially be a new target for drugs to treat diabetes.

Grants UI researcher receives Carver Trust grant

Rajan Sah, MD, PhD, assistant professor of internal medicine in the UI Carver College of Medicine, has recently received a three-year, $400,000 Carver Trust Young Investigator award to study the role of fat-cell expansion in the development of insulin resistance and diabetes.