Ashutosh  Mangalam, PhD. is a professor of pathology at the Carver College of Medicine. A major goal of his research is to develop better treatment options to cure multiple sclerosis (MS). To achieve this goal, his research program focuses on three major interconnected themes: i) utilizing transgenic mice expressing MS susceptible and resistant HLA class II molecules (HLA transgenic mice) to understand the mechanisms of disease pathogenesis; ii) to understand the role of gut microbiome and metabolome in the etiopathogenesis of MS; and iii) test therapeutic efficacy of human gut derived bacteria as drug (BRUG) in animal models of MS.