Sigmund receives NIH grant to study blood vessel health

Sigmund receives NIH grant to study blood vessel health

Curt Sigmund, Ph.D., professor and DEO of pharmacology at the University of Iowa Carver College of Medicine, has been awarded a four-year, $2.48 million grant from the National Institute of Health (NIH) to study a molecular pathway that appears to protect blood vessels from damage caused by cardiovascular stressors, including high-fat diet and aging.

The pathway involves PPAR gamma, a critical protein in the endothelium, the innermost lining of the blood vessel. The research aims to understand the interaction between PPAR gamma and another protein called retinol binding protein 7 (RBP7), which the researchers think may support the beneficial effects of PPAR gamma in the endothelium.

Contacts: 

Curt Sigmund, Pharmacology, 319-335-7604

Jennifer Brown, UI Health Care Marketing and Communications, 319-335-3590