UI research contradicts conventional wisdom about retinal diabetic neuropathy

Finding shows sequence of events is opposite of what was long believed to be true
For many years, scientists believed diabetic patients developed retinopathy and, as a result of damage to the eye’s blood vessels, later developed neuropathy. In this new study, however, researchers discovered that the sequence of events is just the opposite.

Study identifies liver-generated hormone that regulates 'sweet tooth'

A new University of Iowa-led study, published in "Cell Metabolism," has identified a hormone that appears to be linked to sugar cravings and consumption. The research could improve diet and help diabetic and obese patients.

Appointments Abel elected to National Academy of Medicine

Dr. E. Dale Abel, the John B. Stokes III professor in diabetes research, professor of internal medicine and biochemistry, and director of the Fraternal Order of Eagles Diabetes Research Center at the University of Iowa Carver College of Medicine, has been elected to the National Academy of Medicine.

Targeting glucose production in liver may lead to new diabetes therapies

Disabling a critical checkpoint for controlling glucose production in the liver reduces blood sugar levels in mouse models of Type 2 diabetes
A new University of Iowa study shows that a biological checkpoint known as the Mitochondrial Pyruvate Carrier (MPC) is critical for controlling glucose production in the liver and could potentially be a new target for drugs to treat diabetes.

Grants UI researcher receives Carver Trust grant

Rajan Sah, MD, PhD, assistant professor of internal medicine in the UI Carver College of Medicine, has recently received a three-year, $400,000 Carver Trust Young Investigator award to study the role of fat-cell expansion in the development of insulin resistance and diabetes.

Grants Pharmacology researchers earn $3.4 million in grants

Researchers in the UI Department of Pharmacology have received a pair of research grants from the NIH totaling $3.4 million to study new ways to treat obesity, diabetes, and high blood pressure.

Bacteria may cause Type 2 diabetes

Findings suggest anti-bacterial therapy or vaccines may be able to prevent or treat Type 2 diabetes
A UI study shows that chronic exposure to a toxin made by staph bacteria produces in rabbits the hallmark symptoms of Type 2 diabetes, including insulin resistance and glucose intolerance. The findings suggest that eliminating staph bacteria or neutralizing the toxins might have potential for preventing or treating the disease.

Grants Abel awarded $4 million to study heart failure and diabetes

E. Dale Abel, director of the Fraternal Order of Eagles Diabetes Research Center at the University of Iowa, has been awarded two separate grants totaling $4 million from the National Heart Lung and Blood Institute to study the connection between diabetes, obesity, and heart failure.

Grants Taylor receives NIH grant to study glucose production in the liver

Eric Taylor, assistant professor of biochemistry at the University of Iowa Carver College of Medicine, was recently awarded a five-year, $1.87 million grant from the National Institutes of Health to study biological mechanisms used by the liver to make glucose.

New cells may help treat diabetes

UI group creates insulin-producing cells that normalize blood-sugar levels in diabetic mice
Starting from human skin cells, researchers at the University of Iowa have created human insulin-producing cells that respond to glucose and correct blood-sugar levels in diabetic mice. The findings may represent a first step toward developing patient-specific cell replacement therapy for type 1 diabetes.