Targeting glucose production in liver may lead to new diabetes therapies

Disabling a critical checkpoint for controlling glucose production in the liver reduces blood sugar levels in mouse models of Type 2 diabetes
A new University of Iowa study shows that a biological checkpoint known as the Mitochondrial Pyruvate Carrier (MPC) is critical for controlling glucose production in the liver and could potentially be a new target for drugs to treat diabetes.

Grants UI researcher receives Carver Trust grant

Rajan Sah, MD, PhD, assistant professor of internal medicine in the UI Carver College of Medicine, has recently received a three-year, $400,000 Carver Trust Young Investigator award to study the role of fat-cell expansion in the development of insulin resistance and diabetes.

Grants Pharmacology researchers earn $3.4 million in grants

Researchers in the UI Department of Pharmacology have received a pair of research grants from the NIH totaling $3.4 million to study new ways to treat obesity, diabetes, and high blood pressure.

Bacteria may cause Type 2 diabetes

Findings suggest anti-bacterial therapy or vaccines may be able to prevent or treat Type 2 diabetes
A UI study shows that chronic exposure to a toxin made by staph bacteria produces in rabbits the hallmark symptoms of Type 2 diabetes, including insulin resistance and glucose intolerance. The findings suggest that eliminating staph bacteria or neutralizing the toxins might have potential for preventing or treating the disease.

Grants Abel awarded $4 million to study heart failure and diabetes

E. Dale Abel, director of the Fraternal Order of Eagles Diabetes Research Center at the University of Iowa, has been awarded two separate grants totaling $4 million from the National Heart Lung and Blood Institute to study the connection between diabetes, obesity, and heart failure.

Grants Taylor receives NIH grant to study glucose production in the liver

Eric Taylor, assistant professor of biochemistry at the University of Iowa Carver College of Medicine, was recently awarded a five-year, $1.87 million grant from the National Institutes of Health to study biological mechanisms used by the liver to make glucose.

New cells may help treat diabetes

UI group creates insulin-producing cells that normalize blood-sugar levels in diabetic mice
Starting from human skin cells, researchers at the University of Iowa have created human insulin-producing cells that respond to glucose and correct blood-sugar levels in diabetic mice. The findings may represent a first step toward developing patient-specific cell replacement therapy for type 1 diabetes.

Sugar levels may slow brain growth in children with Type 1 diabetes

A new study conducted by the University of Iowa and four other universities found some areas of the brain grow more slowly in children with Type 1 diabetes than those without, according to findings published in Diabetes.
Exterior of Pappajohn Biomedical Discovery Building

UI hosts dedication ceremony for $126 million Pappajohn Biomedical Discovery Building

256,000-square-foot building will be hub of 'high-risk, high-reward' research
The University of Iowa will hold a dedication ceremony Wednesday, Oct. 15, for the $126 million John and Mary Pappajohn Biomedical Discovery Building, which will house “high-risk, high-reward” research in diabetes, deafness, and brain science as well as complex diseases affecting the heart and lungs. Media tours start at 3:15 p.m., followed by a dedication program, ribbon-cutting ceremony, and public reception, and tours.
Keeping Iowans Healthy: Fighting Diabetes

Keeping Iowa Healthy - Diabetes Research Center

Fraternal Order of Eagles gift will propel diabetes research
In this video, Dale Abel, director of the Fraternal Order of Eagles Diabetes Research Center at the University of Iowa, discusses the mission of this center and how a $25 million dollar gift from the Fraternal Order of Eagles will make new advances and understanding possible in the fight against this devastating disease.